[Detection of p53 and MDM2 gene expression in osteosarcoma with biotin-labelled in situ]

¹Bone Tumor Research Laboratory, People's Hospital, Beijing Medical University.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]

|March 1, 1997

Abstract:

We studied the mRNA expression of p53 and MDM2 gene in osteosarcoma. Twenty osteosarcomas were examined with biotin-labelled oligodeoxynucleotide probe in situ. Of 20 tumors, 8 (40%) and 6(30%) showed positive expression of p53 and MDM2 genes, respectively. Among these, 2 tumors revealed co-expression of both p53 and MDM2 genes. This study confirmed the existence of aberrant mRNA expression of p53 and MDM2 genes in osteosarcoma.

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Abstract:

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