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Updated: Aug 2, 2026

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

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Published on: June 11, 2017

[The effect of blocking insulin-like growth factor-1 (IGF-1)-receptor system on tendon cell proliferation]

Z Xiang1, Z Yang, C Zhang

  • 1Department of Orthopedic Surgery, First Univerisity Hospital, West China University of Medical Sciences, Chengdu, P. R. China.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|June 22, 1999
PubMed

The purpose of this study was to find some solutions to the problem of tendon cell proliferation control. Under the condition of in vitro culture, several materials including IGF-1 receptor antibody and mRNA antisense oligonucleotide were added to the culture medium to block the IGF-1-Receptor system. The effect of the material on the tendon cell proliferation was judged by cell count after incubation of 48 hours. The results showed that both IGF-1 Receptor antibody (IGF-1R alpha) and IGF-1 Receptor mRNA antisense oligonucleotide had negative effect on tendon cell proliferation (P < 0.01 and P < 0.05). These findings lead us to think that the above two materials could be used in the experiment of tendon adhesion preventing and living ready-made tendon producing.

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