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Adult de novo acute myeloid leukemias with MLL rearrangements
M del Mar Bellido1, J F Nomdedéu
1Departament d'Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Leukemia Research
|June 22, 1999
Abstract:
MLL gene rearrangements identify a subgroup of acute leukemias with a bad prognosis. Fifty-one adult patients with de novo AML were screened for MLL rearrangements by Southern blot. An unexpected high frequency of AML-M2 according to the FAB classification was found. The most striking morphologic features of these cases were the scarcity of Auer rods and granulocytic dysplasia. Morphologic traits could be helpful in distinguishing molecular groups of AML-M2.