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HIV: a new role for Nef in the spread of HIV
1Division of Microbiology, School of Biochemistry and Molecular Biology,University of Leeds, Leeds LS2 9JT, UK. mharris@bmb.leeds.ac.uk
Current Biology : CB
|June 22, 1999
Abstract:
The HIV Nef protein downregulates the cell-surface expression of the HIV receptor glycoprotein CD4, but the significance of this event has remained obscure. Recent data suggest that Nef reduces cell-surface CD4 to promote the efficient spread of the virus.