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CD1-mediated immune responses to glycolipids
1Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA.
Major advances have recently been accomplished in understanding the biochemistry of interactions between lipid antigens and CD1. The diversity of lipid antigens loaded onto CD1 molecules in normal cells, the ligand requirements for CD1 recognition by autoreactive T cells, including NK T cells, and the significance of CD1-mediated autoreactivity, as opposed to pathogen reactivity, remain controversial issues.
Major advances have recently been accomplished in understanding the biochemistry of interactions between lipid antigens and CD1. The diversity of lipid antigens loaded onto CD1 molecules in normal cells, the ligand requirements for CD1 recognition by autoreactive T cells, including NK T cells, and the significance of CD1-mediated autoreactivity, as opposed to pathogen reactivity, remain controversial issues.