Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane compartmentation and the response to antigen.

R Xavier1, B Seed

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA. xavier@molbio.mgh.harvard.edu

Current Opinion in Immunology
|June 22, 1999
PubMed
Summary

Antigen-receptor engagement relies on plasma membrane microdomains. Disrupting these lipid domains impairs T-cell receptor (TCR) signaling, highlighting their critical role in immune cell communication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLA-B27 did not protect against COVID-19 in patients with axial spondyloarthritis - data from the ReumaCov-Brasil Registry.

Advances in rheumatology (London, England)·2023
Same author

Simple method for removing DOACs from plasma samples.

Thrombosis research·2018
Same author

Spreader grafts: functional or just aesthetical?

Rhinology·2015
Same author

Antibacterial activity of ovary extract from sea urchin Diadema setosum.

European review for medical and pharmacological sciences·2015
Same author

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

Gut·2015
Same author

The intestinal microbiome in type 1 diabetes.

Clinical and experimental immunology·2014

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Antigen-receptor engagement involves intricate signaling molecule rearrangements at the plasma membrane.
  • The plasma membrane is compartmentalized into lipid microdomains with distinct compositions.
  • Lipid-modified proteins associate with these microdomains, influencing antigen-receptor function.

Purpose of the Study:

  • To investigate the role of plasma membrane lipid microdomains in antigen-receptor signaling.
  • To determine the impact of lipid microdomain disruption on T-cell receptor (TCR) signal transduction.

Main Methods:

  • Utilized methods to disrupt plasma membrane lipid microdomains.
  • Assessed the effects of microdomain disruption on TCR signaling pathways.

Related Experiment Videos

Main Results:

  • Disruption of lipid microdomains significantly attenuates TCR signal transduction.
  • Evidence suggests a direct link between lipid microdomain integrity and TCR signaling efficiency.

Conclusions:

  • Plasma membrane lipid microdomains are essential for proper antigen-receptor signaling.
  • Targeting or disrupting these microdomains represents a potential strategy to modulate immune responses.