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Enhancement of activity-dependent calcium increase by neurotrophin-4 in visual cortex pyramidal neurons
1Department of Integrative Brain Science, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. f50207@sakura.kudpc.kyoto-u.ac.jp
Brain Research
|June 22, 1999
Abstract:
In pyramidal neurons from rat visual cortex slices, bath-application of NT-4 (20 ng/ml) did not much affected the baseline calcium signal, but did enhance calcium signals elicited by injections of depolarizing currents (+0.5 nA, 1 s). This enhancing effect of NT-4 was abolished by co-applying K252a. With ryanodine injected intracellularly, the effect of NT-4 was significantly reduced, suggesting an involvement of intracellular calcium release in this NT-4-induced enhancement of calcium transient.