Related Experiment Video

Updated: Aug 6, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

Immunomodulating effects of methionine enkephalin

X Y Li1

  • 1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.

Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|June 22, 1999
PubMed

Methionine enkephalin (Met-Enk), the endogenous neuropeptide, is suggested to be involved in the regulatory loop between immune and neuroendocrine systems. Our studies showed that Met-Enk over a wide range of concentrations increased interleukin-1 (IL-1) production from mouse peritoneal macrophages induced by lipopolysaccharides (LPS) and naloxone did not block the enhancing effect. Met-Enk promoted the proliferation of mouse splenocyte and the production of IL-2 and IL-6 in a dose-dependent manner. The up-regulating effects of IL-2 and IL-6 not only augmented their mRNA transcription but also increased their stability. Thus Met-Enk appears to be an important immunomodulatory signaling molecule to exert regulatory actions concerned with the expressing of pre-inflammatory cytokines.

More Related Videos

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy07:02

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Published on: December 16, 2021

Murine Model of Epicutaneously-Induced Immunomodulation09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...