Using acellular pertussis vaccines for childhood immunization. Potential benefits far outweigh potential risks

If acellular vaccines can offer protection against pertussis that is similar to that afforded by whole-cell vaccines and do so with reduced adverse effects, why have these agents not completely replaced the whole-cell preparations? This article provides an overview of general characteristics of both types of vaccine and some concerns and issues that remain in many physicians' minds. In addition, the authors furnish a rationale and recommendations for safe and appropriate use of the newer acellular formulations.