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Updated: Aug 12, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 24, 2011
A pseudoautosomal boundary-like element adjacent to the SSAV1 locus at 18q21
J H Blusch1, R Brack-Werner, T Werner
1GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany.
Abstract:
Pseudoautosomal boundary-like (PABL) elements have been found at transition sites between genomic regions with different GC-contents. A new PAB related sequence was found immediately adjacent to the S71 provirus on human chromosome 18q21.1-2 (officially designated the SSAV1 locus). The S71 PABL element was full-length as defined by comparison with elements identified at the pseudoautosomal boundaries of the sex chromosomes and in the MHC region. The 3'-ends of all PABL elements showed significant homology to functional CpG-islands, indicating that this similarity is a new common feature of PABL elements.
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