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Related Experiment Videos

La ions in precipitated hydroxyapatites.

I Mayer1, J D Layani, A Givan

  • 1Department of Inorganic and Analytical Chemistry, Hebrew University, Jerusalem, Israel. isaacm@vms.huji.ac.il

Journal of Inorganic Biochemistry
|June 22, 1999
PubMed
Summary
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Lanthanum (La3+) and carbonate were incorporated into hydroxyapatite via precipitation. La3+ was found to be surface-absorbed rather than incorporated into the hydroxyapatite structure.

Area of Science:

  • Materials Science
  • Inorganic Chemistry
  • Biomaterials

Background:

  • Hydroxyapatite (HAp) is a crucial biomaterial with applications in bone regeneration and dental implants.
  • Understanding the incorporation of dopants like lanthanum (La3+) and carbonate is vital for tailoring HAp properties.
  • Previous studies have explored various dopants, but the precise incorporation mechanism of La3+ in HAp requires further elucidation.

Purpose of the Study:

  • To synthesize lanthanum- and carbonate-substituted hydroxyapatites.
  • To investigate the effect of La3+ and carbonate content on HAp structure and thermal stability.
  • To determine the site of La3+ incorporation (surface vs. bulk) within the hydroxyapatite lattice.

Main Methods:

  • Synthesis of hydroxyapatites via aqueous precipitation at controlled pH (7.0).

Related Experiment Videos

  • Doping with varying concentrations of La3+ (0-0.75%) and carbonate (0-6.1%).
  • Characterization using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and luminescence spectroscopy.

    • Main Results:

    • Successful synthesis of hydroxyapatites with incorporated La3+ and carbonate.
    • La3+ uptake was high (90-95%), but Ca/P ratios indicated nonstoichiometry, suggesting surface adsorption.
    • IR spectroscopy confirmed B-type carbonate substitution; lattice parameters remained unaffected by La3+.
    • Thermal analysis revealed water release and carbonate decomposition at specific temperatures.
    • Luminescence data indicated that Gd3+ (used as a probe) was not incorporated, supporting surface adsorption of La3+.

    Conclusions:

    • Lanthanum (La3+) is primarily surface-adsorbed onto hydroxyapatite rather than being incorporated into its crystal structure.
    • B-type carbonate substitution occurs, influencing the nonstoichiometry of the synthesized hydroxyapatites.
    • The thermal stability of hydroxyapatite is affected by adsorbed water and carbonate content.