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Development of Metarhizium anisopliae as a Mycoinsecticide: From Isolation to Field Performance
14:15

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Published on: July 30, 2017

[Etiopathogenesis and therapy of dermatophytosis of the nails]

J Buchvald1

  • 1Dermatovenerologická klinika LF UK a FN, Bratislava.

Casopis Lekaru Ceskych
|June 22, 1999
PubMed

Insights

Mycotic skin infections are increasing due to opportunistic fungi, especially in immunocompromised patients. New antifungal treatments offer improved options for difficult-to-treat conditions like onychomycosis.

Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Context:

  • Rising incidence of mycotic infections affecting skin and adnexa.
  • Increased prevalence in immunocompromised individuals undergoing immunosuppressive therapy (oncological, oncohematological diseases, AIDS).
  • Contributing factors include antibiotic use, hormone therapy, obesity, and occupational predispositions.

Purpose:

  • To review the current landscape of mycotic infections.
  • To discuss the challenges in treating onychomycosis.
  • To present available and novel antifungal agents.

Summary:

  • Mycotic infections are increasingly caused by opportunistic fungi, particularly in patients with compromised immunity.
  • Treatment of onychomycosis remains complex, with historical methods including surgical ablation and keratolytics.
  • Current therapeutic options include griseofulvin, azole derivatives (ketoconazole, fluconazole, itraconazole), allylamines (terbinafine), ciclopiroxolamines, and amorolfin.

Impact:

  • Highlights the growing threat of fungal infections in clinical settings.
  • Emphasizes the need for effective and accessible antifungal treatments.
  • Provides an overview of established and emerging antimycotic agents for clinical consideration.

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