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Transfer RNA modification: influence on translational frameshifting and metabolism
G R Björk1, J M Durand, T G Hagervall
1Department of Microbiology, Umeå University, Sweden. glenn.bjork@micro.umu.se
FEBS Letters
|June 22, 1999
Abstract:
Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.