Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanical behavior of human trabecular bone after overloading.

T M Keaveny1, E F Wachtel, D L Kopperdahl

  • 1Department of Mechanical Engineering, University of California, Berkeley 94720-1740, USA. tmk@me.berkeley.edu

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|June 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of testosterone treatment on the trabecular bone score in older men with low serum testosterone.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture location.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Prediction of incident vertebral fracture using CT-based finite element analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Finite element models predict the location of microdamage in cancellous bone following uniaxial loading.

Journal of biomechanics·2015
Same journal

Mechanical Contribution of the Anterior Talofibular Ligament to Ankle Stability: 3D Anatomical Finite Element Analysis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Repurposing Metformin to Promote Fracture Callus Maturation via AMPK-Driven Metabolic Activation.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Biomechanical Assessment of Functional Tasks Beyond Level Walking Following Total Hip Arthroplasty: A Scoping Review.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Gait Characteristics and Intersegmental Foot and Ankle Motion in Patients With Neglected Achilles Tendon Rupture.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

A Biomechanical Proof-of-Concept Study of Scaffold-Augmented Distraction Osteogenesis Using 3D-Printed Hyperelastic Bone™ in a Rabbit Tibial Lengthening Model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same journal

Predicting Primary Stability of Stemless TSA From Preoperative Bone Density and Surgical Factors.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
See all related articles

Overloading human vertebral trabecular bone significantly degrades its mechanical properties, reducing modulus and strength. This damage, measured by plastic strain, increases fracture risk and is density-dependent.

Area of Science:

  • Biomechanics
  • Materials Science
  • Orthopedics

Background:

  • Osteoporotic fractures are a significant clinical concern.
  • Understanding the mechanical behavior of trabecular bone under stress is crucial for fracture etiology.
  • Previous research has not fully characterized bone's response to overloading.

Purpose of the Study:

  • To characterize the mechanical behavior of human trabecular bone after overloading.
  • To quantify reductions in modulus and strength due to overloading.
  • To determine the dependence of mechanical degradation on applied strain and apparent density.

Main Methods:

  • Destructive compression testing of human L1 vertebral trabecular bone specimens.
  • Loading to strains up to 3.0% at 0.5% strain/second, followed by unloading and reloading.

Related Experiment Videos

  • Quantification of modulus reduction, strength reduction, and residual deformations.

    • Main Results:

    • Reloading stress-strain curves exhibited reduced residual modulus.
    • Mechanical damage, quantified as percent modulus reduction, ranged from 5.2% to 91.0%.
    • Modulus reduction increased with plastic strain; strength reduction increased with plastic strain and decreased with apparent density.

    Conclusions:

    • Occasional overloads can substantially degrade trabecular bone's mechanical properties, increasing fracture risk.
    • Findings provide a basis for biomechanical analysis of damage in trabecular bone.
    • Trends observed in human bone are comparable to bovine bone, suggesting general applicability.