The pathogenesis of vascular thrombosis and its impact in microvascular surgery
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Updated: Oct 20, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
Published on: May 30, 2016
1Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation, OH 44195, USA.
Abstract:
As the use of free tissue transfer becomes more wide-spread, it is important for both the ablative surgeon and the reconstructive surgeon to understand the factors that contribute to successful revascularized tissue transfer. The purpose of this two part review is to provide a basic science overview of the problem of failed free tissue transfers. The first part will focus on the pathogenesis of thrombosis at the anastomotic site, and part two will discuss the pathogenesis of the no-reflow phenomenon. The pathophysiology and therapeutic interventions to prevent and treat anastomotic thrombosis and the no-reflow phenomenon will be discussed.
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