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Related Experiment Videos

Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger.

A H Guse1

  • 1Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany. guse@uke.uni-hamburg.de

Cellular Signalling
|June 22, 1999
PubMed
Summary

Cyclic ADP-ribose (cADPR) mobilizes calcium ions (Ca2+) and acts as a crucial second messenger. This review explores cADPR

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Signaling
  • Physiology

Background:

  • Cyclic ADP-ribose (cADPR) was initially identified as a potent Ca2+-mobilizing compound in sea urchin eggs.
  • Emerging evidence indicates cADPR's role in stimulating Ca2+ signaling across diverse higher eukaryotic cell types.

Purpose of the Study:

  • To review the multifaceted role of cADPR as a Ca2+-mobilizing second messenger.
  • To examine the integration of cADPR metabolism with plasma membrane receptor stimulation.
  • To discuss the characteristics and pharmacological actions of cADPR-mediated Ca2+ release and entry.

Main Methods:

  • Literature review synthesizing existing research on cADPR.
  • Analysis of studies investigating cADPR's effects on calcium signaling pathways.
  • Pharmacological assessment of cADPR's interaction with cellular calcium stores and channels.

Main Results:

  • cADPR stimulates Ca2+ signaling in various mammalian cell types, including muscle, neuronal, and immune cells.
  • The metabolism of cADPR is closely linked to the activation of cell surface receptors.
  • cADPR mediates Ca2+ release from intracellular stores and influences Ca2+ influx.

Conclusions:

  • cADPR functions as a significant second messenger in regulating intracellular calcium levels.
  • Understanding cADPR's mechanisms is vital for comprehending cellular responses in diverse physiological and pathological contexts.
  • Further research into cADPR's pharmacology and its role in Ca2+ entry holds therapeutic potential.

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