Related Experiment Video
Updated: Aug 9, 2026
13:27
Generation of Human CD40-activated B cells
Published on: October 16, 2009
Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation
1Division of Molecular and Genetic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom.
Infection and Immunity
|June 22, 1999
Abstract:
The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.
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