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Published on: December 5, 2017
Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension
M Pravenec1, V Zidek, M Simakova
1Institute of Physiology, Czech Academy of Sciences, Prague.
The Journal of Clinical Investigation
|June 22, 1999
Summary
Chromosome 4 influences blood pressure and metabolic syndrome in spontaneously hypertensive rats (SHRs). Transferring a chromosome 4 segment reduced blood pressure and improved glucose and lipid metabolism, highlighting its role in cardiovascular risk.
Area of Science:
- Genetics
- Cardiovascular Science
- Metabolic Science
Background:
- Essential hypertension is linked to carbohydrate and lipid metabolism disorders.
- A Cd36 gene deletion in spontaneously hypertensive rats (SHRs) is associated with metabolic defects.
- The role of Cd36 and chromosome 4 in blood pressure regulation and cardiovascular risk in SHRs is not fully understood.
Purpose of the Study:
- To investigate the role of chromosome 4, including the Cd36 gene, in blood pressure control and cardiovascular risk factors in SHRs.
- To determine if a specific chromosome 4 segment influences metabolic and cardiovascular phenotypes in SHRs.
Main Methods:
- Development of a congenic strain (SHR. BN-Il6/Npy) by transferring a chromosome 4 segment from Brown Norway (BN) rats to the SHR background.
- Analysis of blood pressure, glucose intolerance, hyperinsulinemia, and hypertriglyceridemia in the congenic strain.
- Genotyping of the Cd36 gene in SHR and stroke-prone SHR strains.
Main Results:
- Transfer of the chromosome 4 segment significantly reduced blood pressure in the congenic rats.
- The congenic rats exhibited amelioration of dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia.
- Cd36 deletion variants were not critical for the initial selection of hypertension in the SHR model, suggesting other linked genes on chromosome 4 are involved.
Conclusions:
- A specific region on chromosome 4 can influence a wide range of cardiovascular risk factors, contributing to the hypertension metabolic syndrome.
- The blood pressure-lowering and metabolic benefits of chromosome 4 in SHRs may be due to linkage of Cd36 with other genes within the transferred segment.
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