Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac hypertrophy: sorting out the circuitry.

T A McKinsey1, E N Olson

  • 1Department of Molecular Biology and Oncology University of Texas Southwestern Medical Center at Dallas, 75235-9148, USA.

Current Opinion in Genetics & Development
|June 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing.

Science advances·2021
Same author

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

Diabetologia·2012
Same author

Transcriptome analysis of subcutaneous adipose tissues in beef cattle using 3' digital gene expression-tag profiling.

Journal of animal science·2011
Same author

Regulatory mechanisms for skeletal muscle differentiation and their relevance to gene expression in the heart.

Trends in cardiovascular medicine·2011
Same author

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development.

Leukemia·2010
Same author

Knowing in your heart what's right.

Trends in cell biology·2007

Cardiac hypertrophy, an enlarged heart, initially compensates for reduced output but can lead to heart failure. Key signaling pathways regulate this adaptive response.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Cellular Physiology

Background:

  • Cardiac hypertrophy is the heart's adaptive enlargement in response to stimuli.
  • While initially compensatory, sustained hypertrophy can lead to heart failure.
  • This process involves intricate intracellular signaling and transcription factor activation.

Purpose of the Study:

  • To summarize recent advancements in understanding cardiac hypertrophy regulation.
  • To highlight key signaling pathways involved in the hypertrophic program.

Main Methods:

  • Literature review of recent findings in cardiac hypertrophy research.
  • Analysis of signaling pathways including G proteins, MAP kinases, and calcium-responsive phosphatases.

Related Experiment Videos

Main Results:

  • Identification of G proteins, MAP kinases, and calcium-responsive phosphatases as critical regulators.
  • Understanding the coupling of signal transduction to transcription factors.

Conclusions:

  • Recent research has elucidated the critical role of specific signaling pathways in cardiac hypertrophy.
  • Further understanding of these pathways is crucial for managing heart conditions.