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Related Experiment Videos

Telomerase: Dr Jekyll or Mr Hyde?

J C Prescott1, E H Blackburn

  • 1University of California San Francisco Deptartment of Microbiology and Immunology San Francisco, California 94143-0414, USA. prescott@socrates.ucsf.edu

Current Opinion in Genetics & Development
|June 23, 1999
PubMed
Summary
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Human telomerase extends cell lifespan and mouse reproduction, but its regulation and role in cancer remain unclear. Further research is vital for telomere-based therapies, balancing potential benefits against risks.

Area of Science:

  • Cellular biology
  • Molecular genetics
  • Biogerontology

Background:

  • Recent advances include ectopic human telomerase expression, increasing cellular replicative lifespan.
  • Mice lacking telomerase have demonstrated viability for multiple generations.
  • Core telomerase activity has been reconstituted in vitro, yet regulatory mechanisms are poorly understood.

Purpose of the Study:

  • To explore the implications of telomerase activity in cellular aging and cancer.
  • To investigate the regulatory mechanisms governing telomerase function.
  • To assess the therapeutic potential and associated risks of telomerase manipulation.

Main Methods:

  • Ectopic expression of human telomerase in cell cultures.
  • Generation and observation of telomerase-deficient mouse models.

Related Experiment Videos

  • In vitro reconstitution of core telomerase activity from diverse organisms.

    • Main Results:

    • Ectopic telomerase expression correlated with increased cellular replicative lifespan.
    • Telomerase-deficient mice exhibited normal lifespans and reproductive capabilities for six generations.
    • Telomerase activation was observed preceding oncogenic transformation in certain human cell types, but not others.

    Conclusions:

    • Telomerase plays a significant role in cellular aging and has complex associations with cancer.
    • Understanding telomerase regulation is crucial for its therapeutic applications.
    • Telomere-based therapies offer promise but require careful consideration of potential adverse effects, particularly concerning oncogenesis.