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Updated: Jul 21, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
QT dispersion is reduced after valve replacement in patients with aortic stenosis
D Darbar1, C J Cherry, D M Kerins
1Department of Medicine, Vanderbilt University and Veterans Administration Medical Center, Nashville, Tennessee, USA.
Objective:
To investigate whether QT dispersion is a reliable index of the severity of aortic stenosis and left ventricular hypertrophy in the setting of aortic stenosis.
Design:
A retrospective analysis of the results of echocardiography and electrocardiography before and after aortic valve replacement.
Setting:
Tertiary centre.
Patients:
36 men (30 white and six black) with symptomatic aortic stenosis requiring valve replacement.
Results:
All patients had significant aortic stenosis (mean (SD) aortic valve area 0.68 (0.18) cm2) and evidence of left ventricular hypertrophy (left ventricular mass index (LVMI): 267 (90) g/m2). Before aortic valve replacement, QT dispersion was correlated with mean aortic valve area and LVMI (r = 0.697, p < 0.001, and r = 0.59, p < 2.4 x 10(-6), respectively). QT dispersion and QT corrected for heart rate dispersion decreased from 133 (54) to 71 (33) ms and from 151 (64) to 94 (76) ms, respectively (p < 0.001 for both). LVMI regressed after aortic valve replacement to 190 (79) g/m2, p < 0.01.
Conclusions:
QT dispersion is increased in association with LVMI in patients with significant symptomatic aortic stenosis. Aortic valve replacement reduces QT dispersion and LVMI. QT dispersion could be a useful indicator of risk and risk reduction in patients with significant symptomatic aortic stenosis.
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