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Ten year survival after heart transplantation: palliative procedure or successful long term treatment?

S Fraund1, K Pethig, U Franke

  • 1Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, 30623 Hannover, Germany.

Heart (British Cardiac Society)
|June 23, 1999
PubMed

Insights

Heart transplantation offers long-term survival for about half of patients, with good exercise capacity and manageable side effects. This study investigated outcomes and prognostic factors in heart transplant recipients.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunosuppression

Background:

  • Heart transplantation is a critical treatment for end-stage heart failure.
  • Understanding long-term outcomes and survival predictors is essential for patient management.

Purpose of the Study:

  • To evaluate the long-term results of heart transplantation.
  • To identify prognostic factors influencing survival after heart transplantation.

Main Methods:

  • Retrospective analysis of 120 heart transplant patients (1984-1987).
  • Assessment of functional status, quality of life, and survival rates.
  • Investigation of potential predictors for long-term survival.

Main Results:

  • Ten-year survival rate was 48%, with 58 patients surviving over 10 years.
  • Leading causes of death included cardiac allograft vasculopathy (39%) and acute rejection (18%).
  • Long-term survivors demonstrated good exercise tolerance and preserved left ventricular function.

Conclusions:

  • Heart transplantation is a valuable therapeutic option for selected patients.
  • Approximately 50% of heart transplant recipients can achieve over 10 years of survival with good functional status.
Abstract

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