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[Cardiac electrophysiological effect and clinical use of adenosine]
1Békés Megyei Képviselötestület Pándy Kálmán Kórház, Gyula, II. Belgyógyászat-Kardiológia.
Insights
Adenosine effectively terminates supraventricular tachycardias by acting on cardiac ion channels. However, this nucleoside can also cause proarrhythmias, necessitating careful clinical application.
Area of Science:
- Cardiology
- Electrophysiology
- Pharmacology
Context:
- Adenosine's role in cardiac electrophysiology is crucial.
- Understanding its effects on ion channels and clinical outcomes is essential.
Purpose:
- To review the cardiac electrophysiological effects of adenosine.
- To discuss its antiarrhythmic and diagnostic applications.
- To highlight potential proarrhythmic side effects.
Summary:
- Intravenous adenosine effectively terminates various tachycardias, including sinus node, AV nodal, and AV-reciprocating reentrant types.
- Adenosine also has diagnostic uses in cardiology.
- Potential proarrhythmias, such as atrial and ventricular arrhythmias, can occur at therapeutic doses (6-12 mg).
Impact:
- Provides a comprehensive overview of adenosine's dual role in cardiac rhythm management.
- Informs clinical practice regarding the safe and effective use of adenosine.
- Highlights the importance of monitoring for adverse effects during adenosine therapy.
Abstract:
A review is provided of the present state of knowledge relating to the cardiac electrophysiological effects of adenosine at ion channel and clinical levels. It is emphasized that intravenous adenosine is highly effective in terminating sinus node, atrioventricular (AV) nodal and AV-reciprocating reentrant tachycardias. In the course of an account of the antiarrhythmic indications of adenosine therapy, the main aspects of the diagnostic use of the nucleoside are briefly discussed. It is pointed out that adenosine treatment may possibly be accompanied by the occurrence of atrial and ventricular proarrhythmias, for at pharmacological dose of 6-12 mg this endogenous cardioprotective and antiarrhythmic agent is not devoid of side-effects.