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Updated: Oct 1, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
[Amyloidosis. A review]
J S Thomsen1, T Horn, P Schlichting
1Patologisk-anatomisk institut, Amtssygehuset i Herlev.
Abstract:
Amyloidosis is a heterogenous group of diseases, all characterized by extracellular deposition of amyloid either systemically or localized. Of wellknown diseases are Alzheimer's dementia, AL-amyloidosis (e.g. in multiple myeloma) and AA-amyloidosis (e.g. in rheumatoid arthritis). Amyloid is composed of three components of which the fibrillary component is the basis of amyloid classification. Many types of amyloid have a systemic distribution and give rise to varying symptoms. The diagnosis is based on biopsy, preferably of abdominal subcutis. The prognosis is poor, however, recent investigations on the three-dimensional structure of the P-component provide hope for future therapy.
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