[Genetics of immune response and vaccines of tomorrow]

The paper deals with the problems in the designing and development of fundamentally new conjugated antigen (hapten, peptide, protein)-polymer immunogens and vaccines and with their introduction into clinical practice. The history of designing conjugated and synthetic immunogens is briefly given. A new principle in the design of artificial vaccinating preparations is considered. The results of study of a genetic control of an immune response to artificial antigens are analyzed. The properties of high-molecular polyions, the molecular and cellular mechanisms of phenotypic correction of genetic control of an immune response to conjugated antigen-polymer complexes are shown. The artificial antigens and vaccinating preparations based on artificial polyions and designed by the author and his colleagues are described. Particular attention is paid to new designed vaccinating preparations, including Grippol which has been permitted for clinical application and manufacture.