Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anorexia and aging: pathophysiology.

J E Morley1, D R Thomas

  • 1Division of Geriatric Medicine, St. Louis University Medical School, Missouri, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|June 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

National TB cohort review evaluation: insights for control strategies in low-incidence settings.

IJTLD open·2026
Same author

A Case of Fatal Poisoning by Nitrobenzene.

The Indian medical gazette·2017
Same author

Cases of Poisoning and Suspected Poisoning. Lecture Given to the Lahore Branch of the British Medical Association.

The Indian medical gazette·2017
Same author

Interpreting Discriminant Functions: A Data Analytic Approach.

Multivariate behavioral research·2016
Same author

Recent outbreaks of infectious syphilis, United Kingdom, January 2012 to April 2014.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2014
Same author

The effect of carnitine on the oxidation of saturated fatty acids by pea cotyledon mitochondria.

Planta·2014
Same journal

Different approaches of strength-to-muscle mass ratio: impact on 24-month outcomes in patients with acute coronary syndrome.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

From scriptural reference to scientific evidence a critical review of the nutritional composition and functional food potential of foods described in classical Islamic texts.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Integrating BIA-derived body composition parameters with GLIM criteria for survival prediction in patients with solid tumors.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Polyunsaturated fatty acids in the prevention, treatment, and survival of breast cancer.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Unpacking the eating pathways: The mediating roles of emotional eating and problem-solving skills in the relationship between childhood trauma and eating expectancies.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Improving communication about dietary fats: development and validation of the Fats-Related Attitude Scale based on data from Brazil, China, Croatia, Poland, and Spain.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
See all related articles

Aging impairs food intake regulation, leading to reduced appetite and early fullness. This physiological anorexia of aging increases risks for malnutrition and weight loss in older adults.

Area of Science:

  • Gerontology
  • Gastroenterology
  • Neuroscience

Background:

  • Aging is associated with decreased food intake and early satiety.
  • Reduced adaptive relaxation of the stomach's fundus leads to premature antral filling.
  • Hormonal changes, including increased cholecystokinin and altered leptin levels, contribute to appetite regulation issues in the elderly.

Purpose of the Study:

  • To investigate the physiological mechanisms underlying the anorexia of aging.
  • To identify key factors contributing to reduced food intake and early satiation in older individuals.

Main Methods:

  • The study reviews existing literature on aging, food intake regulation, and associated physiological changes.
  • Analysis focuses on gastrointestinal function, hormonal influences (cholecystokinin, leptin), and central feeding drives (opioid, neuropeptide Y).

Related Experiment Videos

Main Results:

  • Aging decreases stomach fundus adaptive relaxation, causing early gastric emptying and satiety.
  • Increased cholecystokinin effectiveness contributes to reduced appetite.
  • Central feeding signals, including opioid and neuropeptide Y effects, diminish with age.
  • Leptin levels rise in aging males but not females.

Conclusions:

  • Physiological anorexia of aging is a multifactorial condition involving gastrointestinal, hormonal, and neural changes.
  • This age-related decrease in appetite heightens the vulnerability of older adults to anorexia and weight loss, particularly during illness.