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Growth hormone treatment in a child with Williams-Beuren syndrome: a case report
G M Kuijpers1, M De Vroede, H E Knol
1Department of Endocrinology, Wilhelmina Children's Hospital, Utrecht University, The Netherlands. g.kuijpers@wkz.azu.nl
Unlabelled:
Growth retardation is a consistent finding in Williams-Beuren syndrome. The cause of short stature in this syndrome is unknown. Endocrine studies have failed to reveal abnormalities in the growth hormone-insulin-like growth factor I axis. We report a boy with confirmed Williams-Beuren syndrome, who was found to have classical growth hormone deficiency and responded well to growth hormone therapy.
Conclusion:
Although growth hormone deficiency is not likely to be a common cause of short stature in Williams-Beuren syndrome, we nevertheless recommend evaluation of the growth hormone-insulin-like growth factor I axis in all cases.