Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postmastectomy radiotherapy: randomized trials.

R Arriagada1, L E Rutqvist, M G Lê

  • 1Instituto de Radiomedicina (IRAM), Vitacura, Santiago, Chile.

Seminars in Radiation Oncology
|June 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconciling livestock production and wild herbivore conservation: challenges and opportunities.

Trends in ecology & evolution·2021
Same author

Preoperative radiotherapy in breast cancer patients: 32 years of follow-up.

European journal of cancer (Oxford, England : 1990)·2017
Same author

Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Adjuvant cisplatin-based chemotherapy in nonsmall-cell lung cancer: new insights into the effect on failure type via a multistate approach.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials.

Lancet (London, England)·2011
Same author

Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01).

Annals of oncology : official journal of the European Society for Medical Oncology·2010

Postmastectomy radiotherapy significantly reduces locoregional recurrence risk, especially with more involved axillary nodes. Its impact on distant metastases and survival remains debated due to potential cardiac toxicity.

Area of Science:

  • Oncology
  • Radiotherapy
  • Clinical Trials

Background:

  • Postmastectomy radiotherapy is established to reduce locoregional recurrence.
  • Recurrence risk correlates with the number of involved axillary lymph nodes.
  • The impact on distant metastases and overall survival is less clear.

Purpose of the Study:

  • To summarize the evidence on postmastectomy radiotherapy's effects.
  • To discuss the benefits versus risks of this treatment modality.
  • To highlight the importance of radiation technique.

Main Methods:

  • Review of randomized trials and overviews.
  • Analysis of locoregional recurrence rates based on nodal involvement.
  • Evaluation of data on distant metastases and survival.

Related Experiment Videos

Main Results:

  • Radiotherapy triples the risk reduction of locoregional recurrences.
  • Recurrence rates at 10 years are approximately 25%, 35%, and 55% for 1-3, 4-9, and 10+ involved nodes, respectively.
  • Fewer than 15% of patients with negative nodes relapse locally at 10 years.

Conclusions:

  • Postmastectomy radiotherapy is effective in controlling locoregional disease.
  • The effect on distant spread and survival is controversial, with potential cardiac toxicity.
  • Optimizing radiation techniques is crucial for maximizing survival benefits.