Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postmastectomy radiotherapy: future directions.

L J Pierce1

  • 1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0010, USA.

Seminars in Radiation Oncology
|June 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The HAPPE plus Event-Related (HAPPE+ER) software: A standardized preprocessing pipeline for event-related potential analyses.

Developmental cognitive neuroscience·2022
Same author

Minimizing cardiotoxicity following breast radiotherapy: treatment planning is the key.

Cancer journal (Sudbury, Mass.)·2002
Same author

Treatment guidelines and techniques in delivery of postmastectomy radiotherapy in management of operable breast cancer.

Journal of the National Cancer Institute. Monographs·2002
Same author

Definition of the supraclavicular and infraclavicular nodes: implications for three-dimensional CT-based conformal radiation therapy.

Radiology·2001
Same author

Observations of residual differentiation potential during lineage commitment.

Annals of the New York Academy of Sciences·2001
Same author

Mammographically detected ductal carcinoma in situ of the breast treated with breast-conserving surgery and definitive breast irradiation: long-term outcome and prognostic significance of patient age and margin status.

International journal of radiation oncology, biology, physics·2001
Same journal

Integrative Medicine for Breast Cancer Survivors.

Seminars in radiation oncology·2026
Same journal

Integrative Oncology Approaches for Gastrointestinal Symptoms and Risk Reduction in Patients With Digestive Tract Cancers.

Seminars in radiation oncology·2026
Same journal

Integrative Oncology and Radiation Therapy: An Essential Evolution.

Seminars in radiation oncology·2026
Same journal

Clinical Trials of Integrative Oncology Interventions for Radiation Therapy: Emerging Evidence and Opportunities.

Seminars in radiation oncology·2026
Same journal

Nonpharmacologic Approaches for Pain Management in Patients With Cancer Treated With Radiation Therapy.

Seminars in radiation oncology·2026
Same journal

Integrative Therapies for Radiation-Related Toxicities in Hematological Malignancies.

Seminars in radiation oncology·2026
See all related articles

Radiotherapy after mastectomy significantly reduces local failure and may improve survival. Further research is needed to understand its effects on systemic control and optimize treatment sequencing with chemotherapy.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Postmastectomy radiotherapy is established to reduce local failure and improve survival.
  • Existing studies raise questions about radiotherapy's impact on systemic control and overall benefit.
  • Need for well-designed trials integrating modern surgical and chemotherapy approaches.

Purpose of the Study:

  • Investigate radiotherapy's role in systemic control in the modern era.
  • Evaluate the benefit of comprehensive radiotherapy in moderate-risk patients.
  • Explore optimal sequencing of radiotherapy and chemotherapy.

Main Methods:

  • Analysis of existing postmastectomy radiotherapy studies.
  • Ongoing randomized trials incorporating aggressive surgery and chemotherapy.

Related Experiment Videos

  • Planned trials focusing on regional irradiation and comprehensive radiotherapy.

    • Main Results:

    • Radiotherapy demonstrably reduces local failure and impacts survival.
    • Current research is exploring the systemic effects of radiotherapy.
    • Future trials will address regional irradiation and treatment sequencing.

    Conclusions:

    • Further randomized trials are essential to clarify radiotherapy's systemic benefits.
    • Optimizing radiotherapy techniques and sequencing with chemotherapy is crucial.
    • Modern trials are designed to answer key questions in breast cancer treatment.