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Related Experiment Videos

Experimental side-wall aneurysms: a natural history study.

D F Kallmes1, T A Altes, D A Vincent

  • 1Department of Radiology, University of Virginia Health Sciences, Charlottesville 22908, USA. dfk3b@virginia.edu

Neuroradiology
|June 24, 1999
PubMed
Summary

Canine experimental aneurysms remained open in most cases, showing they are a good model for testing new aneurysm occlusion devices. This study provides control data for future device development.

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Area of Science:

  • Vascular Surgery
  • Biomedical Engineering
  • Animal Models

Background:

  • Developing effective aneurysm occlusion devices requires reliable control data.
  • Understanding the natural history of experimental aneurysms is crucial for validation.

Purpose of the Study:

  • To determine the rate of spontaneous thrombosis in canine experimental side-wall aneurysms.
  • To establish control data for future studies on aneurysm occlusion devices.

Main Methods:

  • Surgically created bilateral common carotid artery vein patch aneurysms in eight mongrel dogs.
  • Utilized Duplex Doppler sonography at 14 days and angiography between 30 and 210 days post-creation.
  • Monitored aneurysm patency and size.

Main Results:

Related Experiment Videos

  • Sonography showed 81% (13 of 16) of aneurysms remained patent.
  • Angiography confirmed sustained patency in all monitored aneurysms up to 200 days.
  • No spontaneous recanalization was observed in initially occluded aneurysms.

Conclusions:

  • The canine side-wall aneurysm model is suitable for evaluating aneurysm occlusion devices.
  • Control aneurysms in this model demonstrate long-term patency, essential for device testing.