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Squamous cell carcinoma with necrotizing scleritis.

N Younan1, K McClellan

  • 1Department of Ophthalmology, University of Sydney, New South Wales, Australia.

Australian and New Zealand Journal of Ophthalmology
|June 24, 1999
PubMed
Summary

Excessive UV-B exposure may increase the risk of ocular surface neoplasia, such as limbal squamous cell carcinoma (SCC), in young, healthy individuals. This case highlights the importance of considering environmental factors in eye conditions.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Dermatology

Background:

  • Squamous cell carcinoma (SCC) is a malignancy of the conjunctiva.
  • Ocular surface neoplasia (OSN) is a spectrum of neoplastic diseases affecting the conjunctiva and cornea.
  • Risk factors for OSN include human papillomavirus (HPV) infection and ultraviolet (UV) radiation exposure.

Observation:

  • A young, healthy, white Australian male presented with a limbal lesion causing a red eye and foreign body sensation.
  • The patient had a history of extensive sun exposure through surfing.
  • Biopsy revealed a well-differentiated SCC arising from conjunctival intraepithelial neoplasia (in situ carcinoma).

Findings:

  • The limbal lesion was diagnosed as squamous cell carcinoma (SCC).

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  • The SCC was successfully excised and treated with a corneoscleral graft.
  • Necrotizing scleritis was a concurrent finding, suggesting a severe inflammatory response.

    • Implications:

    • This case underscores the potential link between excessive UV-B exposure and the development of ocular surface neoplasia (OSN) in young, healthy individuals.
    • Increased prevalence of OSN may be observed in populations with high cumulative UV exposure.
    • Ophthalmologists should consider UV exposure history in the evaluation of limbal lesions, particularly in younger patients.