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Related Experiment Videos

Urinary incontinence and depression.

B H Zorn1, H Montgomery, K Pieper

  • 1Department of Urology, University of Virginia Health Sciences Center, Charlottesville, USA.

The Journal of Urology
|June 24, 1999
PubMed
Summary
This summary is machine-generated.

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Depression is strongly linked to idiopathic urge incontinence, potentially due to altered serotonin function. This finding may explain why antidepressants targeting serotonin are effective treatments for urge incontinence.

Area of Science:

  • Neuroscience
  • Urology
  • Psychiatry

Background:

  • Serotonergic systems are involved in mood regulation and also influence bladder control.
  • Altered serotonin function in depression may contribute to urinary incontinence.

Purpose of the Study:

  • To investigate the association between depression and idiopathic urge incontinence.
  • To explore the potential role of serotonin pathways in this relationship.

Main Methods:

  • Compared 115 incontinent patients with 80 continent controls.
  • Assessed depression history and used the Beck Depression Inventory (BDI).
  • Classified incontinence types using video urodynamics.

Main Results:

  • 30% of incontinent patients had a history of depression or abnormal BDI, compared to 17% of controls (OR 2.3, p=0.044).

Related Experiment Videos

  • 60% of patients with idiopathic urge incontinence showed signs of depression (p<0.001).
  • No increased depression odds were found in patients with stress or urge incontinence due to other causes.

    • Conclusions:

    • A significant association exists between depression and idiopathic urinary incontinence.
    • Altered serotonin function is a likely mechanism underlying this association.
    • This link may inform the use of serotonergic antidepressants for urge incontinence treatment.