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[Long term evolution of the incapacity in schizophrenic patients in maintenance treatment with risperidone]
J Bobes1, M P González, J Gibert
1Area de Psiquiatría,Universidad de Oviedo, Oviedo,Asturias, 33006,España.
Objective:
To determine the evolution of the degree of long term disability (8 months) in a group of schizophrenic outpatients undergoing monotherapy with risperidone. DESIGN, An observational multicentre study of 8 months follow up.
Patients:
354 patients with schizophrenic disorder (ICD-10).
Evaluation:
Baseline, 2, 4 and 8 months.
Instruments:
BPRS, CGI, UKU, WHO/DAS-S.
Results:
a significant decrease in both the global scores and in each of the 4 areas of disability. Improvement in disability depends to a large degree on the improvement of the disorder as shown on the BPRS and CGI. After 8 months, those patients with paranoid subtype and the less severe ones (BPRS and CGI) showed a considerably lesser degree of disability. The final level of disability (square root = 0,61) is narrowly related to the baseline level of disability, the 3 clusters of the final BPRS, the final CGI, gender and the subtype of schizophrenia.