[On the pathogenesis and treatment of erosive gastritis and duodenitis]

The examination of 52 patients with erosive lesion of the gastroduodenal zone (39 patients with erosive gastritis and 13 with erosive duodenitis) has found association of gastroduodenal erosions with changes in intragastric and intraduodenal pressure, gastric concentrations of biliary acids, hormone secretion (gastrin, insulin, hydrocortisone, thyroxine, thyrotropine), with low functional capacity of the mucus in gastric contents, the presence of Helicobacter pylori. Combined treatment with polyphepan and cerucal produced good response in erosive gastritis and duodenitis. Along with relief of the clinical symptoms and erosion epithelization in 96% of the patients, there was a reduction in the cavity pressure and bile acids concentration in gastric contents, normalization of pyloric function, improvement of the function of gastric mucosa protective barrier.