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[The therapy of bronchial asthma]
L M Fabbri1, A Papi, L Corbetta
1Dipartimento di Medicina Clinica e Sperimentale, Università, Ferrara.
Recenti Progressi in Medicina
|June 25, 1999
Summary
Asthma is a chronic airway inflammatory disease causing breathlessness and wheezing. Effective management involves anti-inflammatory controllers and short-acting bronchodilators for symptom relief and exacerbation control.
Area of Science:
- Respiratory Medicine
- Immunology
Context:
- Asthma is a chronic inflammatory airway disorder characterized by eosinophil, mast cell, and T-lymphocyte infiltration.
- Airway inflammation leads to hyperresponsiveness, reversible airflow limitation, and symptoms like wheezing and cough.
Purpose:
- To describe the pathophysiology, clinical manifestations, and therapeutic strategies for asthma.
- To outline current consensus on asthma management, including controller and reliever medications.
Summary:
- Asthma involves airway inflammation and hyperresponsiveness, often worsening at night.
- Pharmacological control utilizes inhaled anti-inflammatory agents (glucocorticoids, cromones) and short-acting bronchodilators.
- Exacerbations necessitate beta-2-agonists, oral glucocorticoids, and in severe cases, oxygen, IV medications, or mechanical ventilation.
Impact:
- Provides a comprehensive overview of asthma for clinicians and researchers.
- Highlights the importance of targeted anti-inflammatory and bronchodilator therapies in asthma management.