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Updated: Oct 20, 2026

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
Published on: November 5, 2021
[Reactivation of Trypanosoma cruzi infection in patients with acquired immunodeficiency syndrome]
M C Galhardo1, I A Martins, A Hasslocher-Moreno
1Laboratório de Pesquisa Clínica e de Anatomia Patológica do Centro de Pesquisa do Hospital Evandro Chagas, Rio de Janeiro, Brasil.
Abstract:
A patient with AIDS and asymptomatic Chagas's disease and positive xenodiagnosis was taking ketoconazole in order to suppress parasitemia and prevent reactivation of Chagas's disease. Ketoconazole was unplanned suspended after 6 months, and the patient was admitted with fever, headache, vomiting, tachycardia, postural hypotension, hepatosplenomegaly, and positive xenodiagnosis one month later. Treatment with benzonidazole was begun leading to suppression of parasitemia. The patient had probability a neurotoxoplasmosis associated and progressed to coma and death with sepsis. No parasite was found in autopsy.
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