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Relationship between CD4+/CD8+ T cell ratio and T cell activation in systemic lupus erythematosus
1Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan.
Scandinavian Journal of Rheumatology
|June 25, 1999
Abstract:
We investigated the relationship between the ratio of CD4+ to CD8+ T cells (CD4/CD8 ratio) and T cell activation, indicated by human leukocyte antigen (HLA)-DR expression, in patients with systemic lupus erythematosus (SLE). We found that the ratio was decreased in SLE patients and that this was significantly related to expression of HLA-DR by CD8+ (but not CD4+) T cells. These findings may assist in understanding the pathogenesis of SLE. In some SLE patients, the CD4/CD8 ratio and HLA-DR expression may be good indicators of therapeutic efficacy.