Subtraction ICG angiography in Harada's disease

Area of Science:

• Ophthalmology
• Medical Imaging
• Choroidal Vasculature

Background:

• Harada's disease involves inflammation of the uvea.
• The role of indocyanine green angiography (ICGA) in Harada's disease requires further elucidation.
• Choroidal lesions are a key feature of Harada's disease.

Purpose of the Study:

• To investigate choroidal lesions in Harada's disease using subtraction ICGA.
• To clarify the significance of ICGA in diagnosing and monitoring Harada's disease.

Main Methods:

• Eight patients with Harada's disease underwent ICGA.
• High-resolution digital fundus camera and computer system were used for image acquisition and processing.
• Image subtraction technique was applied to serial angiograms at various intervals (seconds and minutes).

Main Results:

• Acute Harada's disease showed delayed choroidal filling and intrachoroidal ICG leakage.
• Subtraction ICGA visualized sequential filling of choroidal arteries, choriocapillaris, and veins.
• Delayed choroidal vein filling was evident in subtraction images.
• Treatment improved choroidal filling, visualized by subtraction ICGA.

Conclusions:

• Subtraction ICGA is effective in demonstrating delayed choroidal vein filling in Harada's disease.
• Hyperpermeability of choroidal vessels is associated with delayed venous filling.
• This technique aids in understanding the pathophysiology and monitoring treatment response in Harada's disease.