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Related Experiment Video

Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases
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Relapsing ulcerative colitis associated with spinal cord stimulation.

M A Kemler1, G A Barendse, M Van Kleef

  • 1Department of Surgery, Department of Anaesthesiology, Maastricht University Hospital, Maastricht, The Netherlands. mkeml@shee.azm.nl

Gastroenterology
|June 26, 1999
PubMed
Summary

Spinal cord stimulation (SCS) for pain management may trigger ulcerative colitis relapses. Removing the SCS system restored remission, suggesting electrical currents could impact this inflammatory bowel disease.

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Area of Science:

  • Neurology
  • Gastroenterology
  • Medical Devices

Background:

  • Spinal cord stimulation (SCS) is a prevalent pain therapy.
  • It involves electrodes on the dorsal spinal cord delivering electrical current from an abdominal pulse generator.
  • Ulcerative colitis (UC) is an inflammatory bowel disease.

Observation:

  • A patient with quiescent left-sided ulcerative colitis (UC) underwent SCS implantation for pain.
  • The patient experienced two distinct relapses of UC coinciding with SCS system use.
  • UC remission was achieved and maintained after SCS system explantation.

Findings:

  • This case presents a novel association between SCS and ulcerative colitis.
  • The findings suggest a potential link between electrical stimulation and UC activity.
  • The patient's UC relapsed upon SCS use and resolved upon its removal.

Implications:

  • Electrical currents from SCS devices may influence the pathophysiology of ulcerative colitis.
  • Further research is warranted to explore the interaction between SCS and inflammatory bowel diseases.
  • This case highlights the need to consider potential systemic effects of neuromodulation therapies.