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Updated: Aug 2, 2026

09:56
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
[Synthesis and antiproliferative activity of a novel N-acyl derivative of doxorubicin]
V M Shcherbakov1, V M Devichenskiĭ, E A Vorontsov
1Institute of Biological Medicine, Moscow, Russia.
Bioorganicheskaia Khimiia
|June 26, 1999
Abstract:
Doxorubicin was acylated with estrone 3-hemisuccinate. The modified derivative exhibited high antiproliferative activity in vitro toward cell cultures of the MCF-7 human mammary adenocarcinoma and HepG2 human hepatoma.

