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Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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[Synthesis and antiproliferative activity of a novel N-acyl derivative of doxorubicin]

V M Shcherbakov1, V M Devichenskiĭ, E A Vorontsov

  • 1Institute of Biological Medicine, Moscow, Russia.

Bioorganicheskaia Khimiia
|June 26, 1999
PubMed

Abstract:

Doxorubicin was acylated with estrone 3-hemisuccinate. The modified derivative exhibited high antiproliferative activity in vitro toward cell cultures of the MCF-7 human mammary adenocarcinoma and HepG2 human hepatoma.

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