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Concentration at steady-state after periodic and non-uniform administration of drug
Y Plusquellec1, J De Biasi, J Souhait
1UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
Abstract:
A two-compartment model, with absorption from the gut and elimination from both compartments, is considered in order to express the concentration at any time and at steady-state when a drug is administered repeatedly according to a dosing schedule non-uniformly distributed over a 24-h interval. A time-delay is included to take into account the drug crossing from the gut to the central compartment.