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Resection versus transplantation for hepatocellular carcinoma
C O Esquivel1, E B Keeffe, G Garcia
1Department of Surgery, Stanford University School of Medicine, California, USA. esquivel@stanford.edu
Journal of Gastroenterology and Hepatology
|June 26, 1999
Summary
Hepatocellular carcinoma (HCC) causes over 1 million deaths annually and is often diagnosed late. This review examines surgical outcomes for HCC, focusing on resection and liver transplantation.
Area of Science:
- Hepatology
- Surgical Oncology
- Gastroenterology
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally, with over 1 million fatalities annually.
- Diagnosis is often delayed due to asymptomatic presentation, leading to advanced tumor stages.
- HCC exhibits resistance to conventional therapies like chemotherapy and radiation.
Purpose of the Study:
- To review and analyze the outcomes of surgical interventions for hepatocellular carcinoma.
- To evaluate the efficacy of partial or complete resection and liver transplantation in HCC management.
Main Methods:
- Literature review of studies reporting outcomes after resection or transplantation for HCC.
- Analysis of patient selection criteria and survival data.
Main Results:
- Surgical resection and liver transplantation remain primary treatment modalities for HCC.
- Less than one-third of HCC patients are eligible for surgical treatment at presentation.
- Outcomes vary based on tumor stage, liver function, and surgical approach.
Conclusions:
- Surgical management offers the best chance for cure in eligible HCC patients.
- Improving early detection and patient selection are crucial for better outcomes.
- Further research is needed to optimize treatment strategies for unresectable HCC.