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Possible interaction between new quinolones and immune functions in macrophages
Y Azuma1, M Shinohara, N Murakawa
1Department of Pharmacology, Osaka Dental University, Hirakata, Japan. aazuma@cc.osaka-dent.ac.jp
General Pharmacology
|June 26, 1999
Abstract:
Some of the immunological effects of a variety of new quinolones on chemotaxis and the production of superoxide anion in rat macrophages were studied. All of the new quinolones examined at a dose range of 0.5 to 50 microg/ml significantly inhibited chemotaxis in a dose-dependent manner in rat macrophages. Moreover, the new quinolones at a dose of 0.5 microg/ml were effective in markedly potentiating the generation of superoxide anion. These results indicate that the new quinolones may modulate immune functions in rat macrophages.