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Bioassays for itraconazole blood levels: an interlaboratory collaborative study
F C Odds1, B Dupont, M G Rinaldi
1Janssen Research Foundation, Beerse, Belgium.
The Journal of Antimicrobial Chemotherapy
|June 26, 1999
Abstract:
Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy-itraconazole were used as standards. Despite quantitative variations, the results of the bioassays correlated sufficiently to indicate the relative level of antifungal activity in the test samples.