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Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation
B U Müller1, A Tichelli, J R Passweg
1Department of Medicine, Kantonsspital, University of Basel, Switzerland.
Abstract:
This case describes a 16-year-old woman treated successfully by a bone marrow transplant from her HLA-identical brother for refractory acquired pure red cell aplasia. Conditioning was as for severe aplastic anaemia with cyclophosphamide 4 x 50 mg/kg and antithymocyte globulin. Complete donor type engraftment at 3 months reversed to full autologous reconstitution at 2 years with normal haemopoiesis. The potential implications on pathogenesis of the disease as well as on treatment of autoimmune disorders by stem cell transplantation are discussed.
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