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Gold(I) complexes as antimicrobial agents.
F Novelli1, M Recine, F Sparatore
1Dipartimento di Scienze Farmaceutiche, Università di Genova, Genoa, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|June 29, 1999
Summary
Seven novel gold complexes show potent biocidal activity against various bacteria, fungi, and protozoa. Their effectiveness depends on the specific phosphine and aminothiol ligands, not just gold content.
Area of Science:
- Inorganic Chemistry
- Medicinal Chemistry
- Microbiology
Background:
- Gold complexes are explored for their potential therapeutic applications.
- Biocidal activity of metal complexes is an area of active research.
Purpose of the Study:
- To synthesize and evaluate the biocidal activity of seven novel gold complexes.
- To determine the spectrum of activity against Gram-positive bacteria, Gram-negative bacteria, fungi, and protozoa.
- To understand the structure-activity relationship concerning the ligands.
Main Methods:
- Synthesis of seven gold complexes.
- Microbiological assays to determine activity against various microorganisms.
- Determination of minimum inhibitory concentrations (MIC).
Main Results:
- All synthesized gold complexes exhibited biocidal activity against tested microorganisms, except for Pseudomonas aeruginosa.
- Minimum inhibitory concentrations (MIC) were often below 1 microgram/ml, indicating high potency.
- The biocidal activity was influenced by the nature of the phosphine and aminothiol ligands, not solely by the gold content.
Conclusions:
- The investigated gold complexes possess significant broad-spectrum biocidal properties.
- Ligand structure plays a crucial role in modulating the antimicrobial efficacy of gold complexes.
- These findings suggest potential for developing new antimicrobial agents based on gold coordination chemistry.