Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phytoestrogens and bone.

J J Anderson1, S C Garner

  • 1Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill, USA.

Bailliere'S Clinical Endocrinology and Metabolism
|June 29, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The environmental impact of diet in Latin American populations: a systematic review with meta-analysis.

Public health nutrition·2026
Same author

The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants.

Journal of public health (Oxford, England)·2018
Same author

Erratum to: Quantifying Intrinsic and Extrinsic Contributions to Human Longevity: Application of a Two-Process Vitality Model to the Human Mortality Database.

Demography·2017
Same author

Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort study.

European psychiatry : the journal of the Association of European Psychiatrists·2016
Same author

Adiposity among 132 479 UK Biobank participants; contribution of sugar intake vs other macronutrients.

International journal of epidemiology·2016
Same author

Lampyridae (Coleoptera): A plethora of mollicute associations.

Microbial ecology·2013
Same journal

Phytoestrogen content in foods.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Experimental studies on lignans and cancer.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Reproductive actions of phytoestrogens.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and inhibition of angiogenesis.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and diseases of the prostate gland.

Bailliere's clinical endocrinology and metabolism·1999
See all related articles

Phytoestrogens, particularly soy isoflavones, show potential for improving tissue health and preventing diseases like osteoporosis. However, human studies are needed to confirm their bone-protective effects in post-menopausal women.

Area of Science:

  • Nutritional Science
  • Endocrinology
  • Pharmacology

Background:

  • Phytoestrogens are plant compounds found in most plant foods, with soy isoflavones gaining attention for health benefits.
  • These compounds, including genistein and daidzein, exhibit estrogenic activities, acting as partial agonists or anti-estrogens.
  • Potential applications include enhancing tissue health and preventing diseases such as cardiovascular disease, reproductive cancers, and osteoporosis.

Purpose of the Study:

  • To investigate the health-enhancing and disease-preventing potential of phytoestrogens, with a focus on soy isoflavones.
  • To examine the oestrogenic activities of isoflavones, including their roles as estrogen agonists or anti-estrogens.
  • To evaluate the efficacy of phytoestrogens in bone health, particularly in post-menopausal conditions.

Related Experiment Videos

Main Methods:

  • Review of existing scientific literature on phytoestrogens and their effects.
  • Analysis of studies investigating isoflavones, such as genistein and daidzein, in various models.
  • Examination of rodent models (ovariectomized) and preliminary human studies in post-menopausal women.

Main Results:

  • Soy isoflavones (genistein, daidzein) have demonstrated bone-sparing effects in ovariectomized rodent models.
  • These effects are likely transferable to higher mammalian species.
  • Initial human studies in post-menopausal women show limited positive effects on bone, primarily in the lumbar vertebrae.

Conclusions:

  • Phytoestrogens, especially soy isoflavones, hold promise for improving tissue health and potentially preventing diseases.
  • While rodent studies are encouraging for bone health, human clinical evidence for significant bone-protective effects in post-menopausal women is still limited.
  • Further human studies are required to establish the definitive efficacy of phytoestrogen supplements for human health benefits.