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Related Experiment Videos

Cardiopulmonary dysfunction in cirrhosis.

H Liu1, S S Lee

  • 1Liver Unit, Gastrointestinal Research Group, University of Calgary, Alberta, Canada.

Journal of Gastroenterology and Hepatology
|June 29, 1999
PubMed
Summary
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Diagnosis and treatment of acute central cervical cord injury.

Chinese medical journal·1999
Same author

[Histological evaluation of collagen-hydroxyapatite composite as osseous implants in the repair of mandibular defect].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·1999
Same author

[A new method to repair artery injuries in extremities by phleboplasty of branched vein graft].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·1999
Same author

[Relationship between the expression of transforming growth factor beta type I receptor (T beta R I) and prognosis of hepatocellular carcinoma (HCC)].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·1999
Same author

Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·1999
Same author

Increased nitric oxide synthase expression in aorta of cirrhotic rats.

Life sciences·1999

Cirrhosis causes circulatory issues like abnormal heart function and breathing problems. Understanding these complications is key for managing liver disease and improving patient outcomes.

Area of Science:

  • Cardiology
  • Hepatology
  • Pulmonology

Background:

  • Cirrhosis presents with complex circulatory dysfunctions.
  • Key abnormalities include hyperkinetic circulation, hepatopulmonary syndromes, and cirrhotic cardiomyopathy.
  • These conditions significantly impact patient prognosis and treatment strategies.

Purpose of the Study:

  • To review the spectrum of circulatory abnormalities in cirrhosis.
  • To elucidate the pathogenesis and clinical significance of hepatopulmonary syndromes and cirrhotic cardiomyopathy.
  • To highlight the implications for liver transplantation.

Main Methods:

  • Literature review of circulatory abnormalities in cirrhosis.
  • Analysis of the pathophysiology of hepatopulmonary syndromes and cirrhotic cardiomyopathy.

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  • Discussion of clinical manifestations and management considerations.

    • Main Results:

    • Hepatopulmonary syndrome, characterized by hypoxemia, is common, though often subclinical.
    • Significant pulmonary hypertension affects 0.2-0.7% of cirrhotic patients.
    • Cirrhotic cardiomyopathy involves impaired left ventricular function, particularly under stress, impacting post-transplant outcomes.

    Conclusions:

    • Circulatory abnormalities are integral to cirrhosis, affecting multiple organ systems.
    • Nitric oxide and altered beta-adrenergic function are implicated in pathogenesis.
    • Recognition and management of these cardiovascular complications are crucial for improving survival in cirrhotic patients, especially those undergoing liver transplantation.