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Related Experiment Videos

Dorzolamide, visual function and ocular hemodynamics in normal-tension glaucoma.

A Harris1, O Arend, L Kagemann

  • 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202-5175, USA.

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
|June 29, 1999
PubMed
Summary

Topical dorzolamide eye drops significantly improved vision and lowered eye pressure in normal-tension glaucoma patients. This carbonic anhydrase inhibitor enhanced contrast sensitivity and ocular blood flow.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Ocular Pharmacology

Background:

  • Normal-tension glaucoma (NTG) is a progressive optic neuropathy.
  • Visual field defects and ocular blood flow alterations are key concerns in NTG management.
  • Carbonic anhydrase inhibitors are used to manage intraocular pressure (IOP).

Purpose of the Study:

  • To investigate the effects of topical dorzolamide on visual function and ocular hemodynamics in NTG patients.
  • To assess changes in contrast sensitivity, IOP, and ocular blood flow parameters.

Main Methods:

  • A randomized, placebo-controlled study involving 18 NTG patients treated with 2% dorzolamide and 11 with placebo for four weeks.
  • Evaluations included contrast sensitivity, IOP, retinal arteriovenous passage time, arterial/venous diameters, and retrobulbar vessel flow velocities.

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  • Measurements were taken at baseline, two weeks, and four weeks.

    • Main Results:

    • Dorzolamide significantly reduced IOP (p<0.01) and increased contrast sensitivity at 3 and 6 cycles/degree (p<0.05) after two and four weeks.
    • Retinal arteriovenous passage time was accelerated by dorzolamide (p<0.05) without altering retinal vessel diameters.
    • No significant changes in IOP or contrast sensitivity were observed in the placebo group.
    • Dorzolamide did not affect flow velocities in retrobulbar vessels.

    Conclusions:

    • Topical dorzolamide effectively reduces IOP and improves contrast sensitivity in NTG patients.
    • The visual function improvement may be linked to IOP reduction or enhanced ocular perfusion.
    • Dorzolamide shows potential as a therapeutic agent for managing visual function in normal-tension glaucoma.