Related Experiment Videos
Innovative technology for tissue disruption by explosive-induced shock waves.
T Kodama1, H Uenohara, K Takayama
1Shock Wave Research Center, Tohoku University, Japan. kodama@helix.mgh.harvard.edu
Ultrasound in Medicine & Biology
|July 1, 1999
Summary
A new, minimally invasive shock wave device can be inserted into the body to disrupt cells. This novel technology uses an explosive shock wave to cause local cell damage and elongation, confirmed by tissue injury observations.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Surgical Technology
Background:
- Minimally invasive procedures are crucial for reducing patient trauma.
- Precise, localized cellular disruption is a goal in various medical interventions.
- Existing shock wave technologies may have limitations in accessibility and control.
Purpose of the Study:
- To develop and evaluate a novel, percutaneously insertable shock wave source.
- To demonstrate the capability of localized cell disruption using this new device.
- To assess the physical effects of the generated shock waves on biological tissue.
Main Methods:
- Development of a shock wave source comprising an explosive, optical fiber, balloon catheter, and Nd:YAG laser.
- Percutaneous introduction of the device to target locations within biological systems.
- Observation and analysis of tissue response and cellular changes post-shock wave application.
Main Results:
- Successful percutaneous delivery of a spherical explosive shock wave source.
- Confirmation of the device's potential to cause localized tissue injury.
- Observed cellular elongation and splitting aligned with the shock wave's direction.
Conclusions:
- The novel shock wave source offers a less invasive method for localized cell disruption.
- The technology demonstrates potential for targeted cellular manipulation in vivo.
- Further research can explore therapeutic applications of this controlled shock wave delivery system.